High dose vitamin C found to be a safe and effective addition to cancer treatment

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iv-vitamin-c-bag(NaturalHealth365) It’s official: Vitamin C can not only be safely combined with conventional cancer treatment, but it can lead to better survival outcomes, and a longer life, for people suffering from glioblastoma – a highly aggressive form of brain cancer.

In research published just last month, researchers used doses of vitamin C that were from 800 to 1,000 times higher than the recommended daily amount – all without major adverse effects. The only question, now, is when will Western medicine fully embrace the use of vitamin C for cancer patients?

Nine-month study explored effects of high-dose vitamin C on brain cancer

In a Phase I safety trial published last month in Cancer Cell, researchers at the University of Iowa gave brain cancer patients three infusions of vitamin C a week for two months, then two infusions a week for seven months. Patients also received standard cancer care, including radiation and chemotherapy.

With a half-life of only two hours in humans, vitamin C must be used in large amounts to achieve the high blood concentrations necessary for therapeutic effects. In this study, the researchers wanted to raise the participants’ blood concentrations of vitamin C to a sky-high 2,000 micromoles – in contrast to the 70 micromoles normally found in adults.

Natural health experts have long insisted that vitamin C must be administered in high doses in order to be successful, and attribute the sometimes-disappointing results of anti-cancer vitamin C studies to insufficient doses.

The key question: What did the study show?

The results of the Phase I safety trial were extremely encouraging. Patients experienced an increase in overall survival time of 4 to 6 months – thereby allowing them to survive for a total of 18 to 22 months – almost two years – as opposed to the typical 14 to 16 months.

Researchers noted that the vitamin C was well tolerated, and featured only minor side effects such as dry mouth – along with rare, fleeting episodes of elevated blood pressure.

Calling the results “promising,” the study authors said they were “guardedly optimistic” about vitamin C’s cancer-fighting potential — pending the results of the Phase II trials. (of course, one can only wonder how these patients would have done with additional non-toxic cancer therapies)

Vitamin C works against cancer by selectively targeting the “Achilles heel” of cancer cells

According to researchers, a specific pathway of altered iron metabolism in cancer cells gives them a fatal weakness that allows vitamin C to sensitize them to radiation and chemotherapy – triggering their death, while making remaining cells more susceptible to standard cancer treatment.

The key to vitamin C’s powers is the fact that it is a “redox active” compound, making it effective on tumor tissues – which have unusually high levels of redox active iron molecules caused by abnormal mitochondrial metabolism.

These molecules react with vitamin C to form hydrogen peroxide and accompanying free radicals, which then cause damage to the DNA of cancer cells – all without harming normal, healthy cells.

Earlier studies support vitamin C’s cancer-fighting effects

Although this is the most recent study on vitamin C’s cancer-fighting powers, it is by no means the only one. Past research has shown that a combination of intravenous high-dose vitamin C and chemotherapy drugs helped to slow the progression of cancer, while alleviating side effects of chemotherapy drugs.

In a 2015 study conducted at Weill Cornell Medicine in New York, researchers found that high-dose vitamin C caused oxidative damage in cancer cells, resulting in impaired tumor growth in colorectal tumors.

And, it used an interesting mechanism to do so.

Normally, a small amount of vitamin C always becomes oxidized into dehydroascorbic acid, or DHA, which acts as a “Trojan horse” in cancer cells. As DHA, it can freely enter cancer cells – something that doesn’t happen with ascorbic acid.

The cancer cells automatically try to convert the DHA back to ascorbic acid – but deplete their antioxidants and die in the process.

Because glucose transport protein helps with the entry of DHA into cells, researchers believe that high-dose vitamin C may work particularly well on cancer cells – such as the KRAS- and BRAF- mutant cells of colorectal cancer, that have high levels of this protein.

Phase II clinical trials are the next step for high-dose vitamin C

Research into vitamin C’s anticancer effects is ongoing, with researchers currently enrolling patients with Stage 4 lung cancer and glioblastoma in Phase II clinical trials. In Phase II studies, patients receive the highest dose of the treatment that did not cause harmful effects in the Phase 1 section.

As with the Phase I trial, researchers are eager find out more about vitamin C’s ability to extend lifespan and improve quality of life for patients undergoing radiation and chemotherapy.

Incidentally, the entire nine-month protocol of vitamin C treatment carried an $8,000 price tag above standard insurance billing – less than the cost of a single dose of some immunotherapy and chemotherapy drugs.

Safe, non-toxic , low-cost and effective, vitamin C seems poised to take its place as a promising cancer treatment of the twenty-first century.

Sources for this article include:


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  • Arnold Kanton

    How can it not be a safe addition to treatment. The establishment make it sound like all vitamins and minerals are a danger. This means many patients are under the impression that only standard treatment is safe. What is wrong with this picture?

    What is wrong is the patients and the public may believe it.

    • Mantle Mickey

      Do not rely on the chemo and radiation period. If a tumor is pushing against a vital organ, radiation MAY shink it for you, however pharma is very horrible last choice. See my other post here.

  • Janet Elkins

    What I would hope that vitamin C becomes a stand alone treatment. This would eliminate all the horrific side effects of the standard protocol.

  • Victor

    I think there is already enough proof of the efficiency of vitamin C. They are testing this more then they test pharmaceutical drugs including Chemotherapy. Could be the drugs that bring profits get to be marketed first.

  • Brenda Terry

    How long does it take for these genius to realize that vitamin C has a great track record for safety. Also, people low on this and other nutrients have an immune system that isn’t operating as it should.

  • Mantle Mickey

    Number one, you do not need intravenous vitamin C and second, to take vitamin C with the pharma poisons just works against vitamin c. At the same time, we are not looking to prolong life 2 years. We are working on the cure and a minimum of vitamin c of 8,000 – 10,000 mgs daily is a good start when diagnosed with cancer. You can take more also. It will not hurt you. Take this with ginger root powder or an extract form of ginger root every single day. Its cheap and it works. Try to exercise also as lymph glands need movement to move on poisons. If you can get medical cannabis in your state take this also, a pinch under tongue, twice daily if it is oil extract. To get full benefit, you want the thc with it. AND AVOID ALL SUGAR AS THIS FEEDS THE CANCER.

  • Mantle Mickey

    Natural health, you are compromising here with big pharma. Love your site, however your post is anything but positive, and contrary to other opinions the body can process megadoses of vitamin c orally. This intravenous nonsense is a money maker for the naturalist. Everyone wants to get in on the $$

  • signalfire1

    I read recently (somewhere, sorry I can’t remember) that polio could have been cured by Vitamin C supplements. Instead we got Salk ‘vaccines’ laden with simian cancer viruses.